Patients Receiving Integrative Medicine Interventions Effectiveness Registry (PRIMIER)

primierPractice-based data collection is widely used across clinical settings for monitoring diseases, conditions, health services, and device safety. These databases are critical to the development of a more complete knowledge base of any field of medicine. In 2011, The Bravewell Collaborative launched the PRIMIER study, Patients Receiving Integrative Medicine Interventions Effectiveness Registry, through BraveNet, its practice-based research network.

Centers participating in PRIMIER are regularly collecting patient-reported outcomes and extracted electronic health record data into a large dataset. This registry utilizes the Patient-Reported Outcomes Measurement System (PROMIS) developed by the National Institutes of Health (NIH), which is a web-based survey that collects patient-reported data on key health symptoms and health-related quality of life, including pain, depression, fatigue, and physical function. These data, grouped by health condition, are easily matched with data regarding laboratory tests, patient functionality, and other measures routinely collected in patients’ medical records.

By clustering participants at the multiple clinical sites with the same medical condition, researchers are able to conduct innovative research by comparing the impact of various integrative therapies on patient-reported and clinical outcomes.  PRIMIER also provides much-needed clinical information on which real-world approaches to common clinical problems appear most effective, and which appear ineffective.  In essence, PRIMIER provides the framework for discovering the “best practices” of integrative medicine.

Participating clinics include:

  • Alliance Institute for Integrative Medicine, Cincinnati, Ohio
  • Boston Medical Center, Boston University, Boston, Massachusetts
  • Integrative Medicine at the University of Colorado Denver, Denver, Colorado
  • Duke Integrative Medicine, Duke University, Durham, North Carolina
  • Jefferson-Myrna Brind Center for Integrative Medicine, Thomas Jefferson Medical College, Philadelphia, Pennsylvania
  • Center for Integrative Medicine, University of Maryland School of Medicine, Baltimore, Maryland
  • Mount Sinai Beth Israel Center for Health and Healing, New York, New York
  • Osher Center for Integrative Medicine at Northwestern University, Chicago, Illinois
  • UCSF Osher Center for Integrative Medicine, University of California, San Francisco, California
  • Penny George Institute for Health and Healing, Allina Health, Minneapolis, Minnesota
  • University of Pittsburgh Center for Integrative Medicine, Pittsburgh, Pennsylvania
  • Scripps Center for Integrative Medicine, Scripps Health, La Jolla, California
  • Simms/Mann Health and Wellness Center, Program in Integrative Medicine, Venice Family Clinic, Los Angeles, California
  • Osher Center for Integrative Medicine at Vanderbilt University, Nashville, Tennessee
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