Molecular Effects of Mind-Body Intervention on Glucocorticoid Sensitivity and Immune Function

The goal of this project is to develop a more detailed mechanistic understanding of neuroendocrine regulation of immune responses through the refinement and validation of novel flow cytometric assays for the assessment of glucocorticoid receptor expression and function. The novel assays will then be used to determine whether in vivo cortisol levels correlate with glucocorticoid receptor expression in immune cells.

Lastly, these novel flow cytometry-based assays will be used to understand how mind-body interventions might “reset” this important bi-directional communication between the neuroendocrine and immune system. This research will form the basis for a larger, more comprehensive investigation of the mechanisms by which mind-body intervention changes neuroendocrine signaling and immune system function.

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